Institut de Recerca Biomèdica (IRB Barcelona)
Life & Medical Sciences
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Research interests
Our laboratory investigates the process of protein synthesis, its evolution, and its connections to human health. We are preoccupied by two fundamental questions: what are the functional limits of the protein synthesis apparatus, and how is protein synthesis regulated and integrated within the context of the cell. We want to understand what defines the boundaries of the proteomes of species, and what specific adaptations allow certain organisms to fabricate proteins that are inaccessible to other species. In addition, we are studying protein synthesis in the mitochondria, with a particular emphasis on the mechanisms that coordinate mitochondrial protein synthesis to mitochondrial dynamics and cell cycle. How these biosynthetic routes are coordinated, and how are they synchronized with the cell cycle is unknown. We want to contribute to the resolution of this problem through the study of an essential mitochondrial protein that we discovered in the lab. Finally, we want to investigate the role of tRNA dynamics in the control of the cellular response to external insults in the form of inflammation. To that end we are developing a new model for the study of human inflammation based on the analysis of resected pediatric vermicular appendices.
