Institut de Recerca Biomèdica (IRB Barcelona)
Life & Medical Sciences
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Research interests
The group investigates how external signals are interpreted by cells to modulate their proliferation, differentiation and survival, focusing on the p38 MAPK pathway. Current work addresses the role of p38 MAPKs in tumor development and chemoresistance mechanisms both by regulating the fitness of the cancer cell and by controlling the cross talk between cancer cells and stromal cells in the tumor microenvironment. We use a combination of biochemical approaches and chemical tools with studies in established cell lines and primary cell cultures, as well as in vivo experiments using mouse models. Our goal is to identify therapeutic opportunities based on the modulation of p38 MAPK signaling. We are also performing screenings to find actionable targets that can be used to boost current therapeutic approaches and to design new targeted therapies for highly heterogeneous and chemoresistant tumors.
