Secreted splicing variant of Klotho for treating muscle disorders

PCT/EP2023/083910The present invention relates to the field of medicine, in particular, it relates to medical approaches for preventing and/or treating muscle disorders. The compounds of the invention are particularly useful for the treatment of age-related muscle disorders.The present invention provides a polypeptide consisting of sequence SEQ ID NO: 1 or a variant thereof consisting of a sequence at least 85% identical to SEQ ID NO:1, for use in the prevention and/or treatment of a muscle disease or disorder. The invention also provides nucleic acid sequence that encodes the polypeptide, a gene construct comprising the nucleic acid sequence, or an expression vector comprising the gene construct for said use. The plypeptide, nucleic acid sequence, gene construct, or expression vector of the invention may be administered in the form of a pharmaceutical composition together with at least one pharmaceutically acceptable excipient, diluent or carrier. The invention also provides a non-therapeutic method for improving muscle function and/or increasing muscle mass of a subject.