Back to agendaABSTRACT
Speakers: ICREA Research Professors Salvador Aznar Benitah (IRB Barcelona) and Luciano Di Croce (CRG)
When: 9th of April 2019, 09:00h
Where: Hotel Catalonia Plaça Catalunya, Bergara, 11, 08002 Barcelona
Abstracts:
Salvador Aznar Benitah
My laboratory is interested in studying how adult stem cells maintain tissue homeostasis, and why stem cells fail to function properly during ageing and tumorigenesis. In last years, we have been particularly interested in understanding how the timing of stem cell function is coordinated (i.e. biological clocks), how stem cells from distant tissues communicate to coordinate their function at the organismal level, and how their epigenome adapts from steady-state conditions to situations of stress.
I will present our latest data regarding the impact our diet has on the clock of stem cells and surrounding niche cells, and its profound effect on stem cell ageing. I will also discuss our recent finding on metastatic-initiating cells and how their metastatic potential is fully dependent on dietary fatty acids.
Luciano Di Croce
Our lab is interested in understanding how epigenetic modifications and chromatin changes are established and, once in place, how they affect gene expression, cell differentiation and transformation.
Polycomb and MLL/Trithorax complexes are evolutionarily conserved chromatin-modifying factors originally identified as part of an epigenetic cellular memory system that maintains repressed or active gene expression states.
I will discuss how Polycomb and MLL proteins (including novel associated factors) impact on transcription, genome architecture, and their role in stem cell biology and cancer.
The ICREA colloquia are a great way to learn about remote fields of research from our best experts. We usually have two speakers, who offer their opinions on the same subject from very different angles. They are open to all ICREAs and their guests.
